Passionate about comedy since an early age, Mélanie Bernier decided to try the Improvisation Comedy League at the age of 14. She got her first role in 1999 in Rends-moi mon nom, a TV film.
She quickly moves onto cinema and appears in Barnie et ses petites contrariétés, next to Fabrice Luchini, Nathalie Baye and Marie Gillain.
In 2011, she returns to TV with several films and joins Marie-France Pisier and Bérénice Bejo in Comme un Avion.
In 2005, she stars in Le temps des porte-plumes with Jean-Paul Rouve, Anne Brochet and Denis Podalydès. She appears also in the TV movie L’Empire du tigre next to Bernard Giraudeau, Nadia Farès and Thierry Frémont.
In 2007, she gives the line to Muriel Robin in the fiction Marie Besnard, l’Empoisonneuse, then shoots Modern Love, in 2008 with Bérénice Bejo.
In 2010, she is chosen by Jean Becker to appear in My Afternoons with Marguerite / La Tête en Friche next to Gérard Depardieu and Gisèle Casadesus.
She shares the bill with Julie Ferrier in Le Fil d’Ariane, a TV film by Marion Laine in 2011. That same year, Mélanie Bernier starts in various films such as The Assault / L’Assaut, Titeuf, the Movie and Delicacy / La Délicatesse.
In 2012, she plays next to Romain Duris and Déborah François in the movie Populaire by Régis Roisnard.
She then obtains a role in three movies ; Gibraltar, The Scapegoat / Au Bonheur des Ogres and The Brats / Les Gamins, all released in 2013.